Gut-Skin Axis & Its Effect On Psoriasis

Introduction

The skin and the gut have a unique connection. The gut system is home to trillions of microorganisms that help metabolize the body’s homeostasis while keeping the immune system functioning for the body to be working correctly. The skin has its set of functions as well as it is the largest organ and helps protect the body from external factors from harm. When these disruptive factors start to affect either the gut or the skin, it can lead to numerous conditions that cause the body to be dysfunctional. When the gut becomes affected by these disruptive factors, it can cause gut disorders and inflammation, affecting the skin and causing disruptions. Today’s article will discuss a skin disorder known as psoriasis and how the gut-skin connection is affected by psoriasis. Referring patients to certified, skilled providers who specialize in gastroenterology treatments. We provide guidance to our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is critical for asking insightful questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

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What Is Psoriasis?

Do you have severe itching along your face and arms? Do certain foods seem to aggravate your digestive tract or skin? Or have you experienced any gut disorders that are affecting your wellbeing? Many of these symptoms are signs of inflammatory issues affecting the gut and are associated with a skin disorder known as psoriasis. Research studies have defined psoriasis as a chronic inflammatory skin disease that is an autoimmune process in which abnormal differentiation and hyper-proliferation of the epidermis occur with redness and scaling. Psoriasis affects about 2% of the general population in the world and is an autoimmune process driven by abnormally activated helper T cells. Additional studies have mentioned that psoriasis is sustained by inflammation that causes the keratinocyte proliferation to be uncontrollable and has dysfunctional differentiation. The inflammatory pathways activate psoriasis in different body locations, causing the individual to become miserable because they are itching and becoming miserable.

An Overview Of Psoriasis-Video

Do you have scaly, patchy lesions in certain areas of your body? Do you feel any gut issues affecting you constantly? Do you feel inflammatory effects disrupting your gut and skin? Many of these conditions are signs that you are experiencing gut disorders associated with a skin disorder known as psoriasis. The video above explains how the gut and skin are affected due to psoriasis and how to heal it naturally. Research studies have mentioned that when the individual is suffering from psoriasis-prone skin, it is due to the alternation of the gut microbiota. When a person scratches the area where psoriasis is formed, it might damage the skin and cause the bacteria to colonize while invoking inflammation to occur in the affected area. Additional research has found that gut disorders like IBD (inflammatory bowel disease) and psoriasis are interlinked due to the increased interaction of inflammatory receptor pathogens disrupting the body’s immune cells.

How The Gut-Skin Connection Is Affected By Psoriasis

The gut is home to trillions of microorganisms that help metabolize the body’s homeostasis while regulating the immune system. Since the body inhabits microorganisms in various locations, including the skin and gut, it helps maintain homeostasis. The skin helps protect the body from external factors and has bidirectional communication with the gut system. However, like with any autoimmune process, it always starts with the gut. Research studies have mentioned that psoriasis is a multifactorial chronic skin disease that infiltrates the body’s immune cells, causing an increase in skin inflammation and making a person’s life miserable. With the gut system also being inflicted by inflammatory markers, many suffering individuals will experience IBD, SIBO, and other gut disorders that can disrupt the body. Additional information has shown that changes in the microflora in the gut-skin axis from genetic or environmental factors can contribute to various diseases. But when these factors begin to cause an increase in inflammatory markers in the body, it can affect a person’s quality of life through habits that make them miserable.

Conclusion

The body needs the gut and skin to maintain homeostasis and metabolize the immune system. The gut microbiota helps transport the nutrients that the body needs and regulates the body’s immunity, while the skin protects the body from outside factors while being the largest organ. The gut and skin have a bi-directional connection that allows them to keep the body from suffering from dysbiosis. When disruptive factors affect either the gut or the skin, it can lead to many disorders and make a person’s life miserable. The skin suffers from a condition known as psoriasis, a chronic inflammatory disease that causes itchy, patchy lesions that can affect the areas around the body. Psoriasis is associated with gut disorders, as many factors aggravate the inflammatory markers and can be a nuisance if not treated early. Incorporating small changes that benefit both the gut and skin health can help relieve the individual from psoriasis and bring back their quality of life.

References

Chen, Lihui, et al. “Skin and Gut Microbiome in Psoriasis: Gaining Insight into the Pathophysiology of It and Finding Novel Therapeutic Strategies.” Frontiers in Microbiology, Frontiers Media S.A., 15 Dec. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7769758/.

De Francesco, Maria Antonia, and Arnaldo Caruso. “The Gut Microbiome in Psoriasis and Crohn’s Disease: Is Its Perturbation a Common Denominator for Their Pathogenesis?” Vaccines, MDPI, 5 Feb. 2022, www.ncbi.nlm.nih.gov/pmc/articles/PMC8877283/.

Ellis, Samantha R, et al. “The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions.” Microorganisms, MDPI, 11 Nov. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6920876/.

Nair, Pragya A, and Talel Badri. “Psoriasis.” In: StatPearls [Internet]. Treasure Island (FL), StatPearls Publishing, 6 Apr. 2022, www.ncbi.nlm.nih.gov/books/NBK448194/.

Olejniczak-Staruch, Irmina, et al. “Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis.” International Journal of Molecular Sciences, MDPI, 13 Apr. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8069836/.

Rendon, Adriana, and Knut Schäkel. “Psoriasis Pathogenesis and Treatment.” International Journal of Molecular Sciences, MDPI, 23 Mar. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6471628/.

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